prostaglandins made by cox-2 enzymes are made in response to injury or contamination, regulating infection. most nsaids work non-selectively on each enzymes (except for celecoxib that's a cox-2 inhibitor). this loss of selectivity will become an trouble due to the fact pain and inflammation alleviation from nsaids come from blocking off cox-2, but alas cox-1 is likewise blocked, inflicting undesirable adverse aspect effects.
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